Restylane ReFyne is a hyaluronic acid dermal filler formulated with XpresHAn Technology™ and is used to soften moderate to severe facial wrinkles and folds, including nasolabial folds (smiles lines) and marionette lines (lines from the corner of your mouth down towards your chin). This special technology allows the dermal filler to move within the face with your own natural expression. A treatment with Restylane ReFyne gives you results that help maintain natural movement when you’re smiling, frowning, and even puckering up. We love this product for rejuvenating the lower face and for the lips.
Why Patients Choose Restylane ReFyne:
Restylane Refyne is formulated to move naturally with your facial expressions, making it an excellent option for areas of the face that are constantly in motion. It helps soften smile lines and other moderate facial folds while maintaining a soft, natural appearance.
Pairs Well With:
- Neuromodulators
- SkinVive
- Replenix Hyaluronic Acid Hydration Serum
- Alastin Restorative Eye Treatment
- Alastin HydraTint Pro Mineral Broad Spectrum Sunscreen SPF 36
Frequently Asked Questions
What is Restylane Refyne?
Restylane Refyne is an FDA-approved hyaluronic acid dermal filler used to correct moderate facial wrinkles and folds, such as nasolabial folds, in adults over the age of 21. It contains lidocaine to improve treatment comfort.
What areas can Restylane Refyne treat?
Restylane Refyne is commonly used to improve the appearance of:
- Nasolabial folds (smile lines)
- Marionette lines
- Other moderate facial wrinkles and folds
Your treatment plan is always customized to your facial anatomy and aesthetic goals.
How is Restylane Refyne different from Restylane Defyne?
Both fillers are designed to move naturally with your facial expressions. Patients often choose Restylane Refyne for moderate facial lines and subtle rejuvenation, while Restylane Defyne provides additional support for deeper folds and areas that require greater structural reinforcement.
How long does Restylane Refyne last?
Many patients enjoy results for up to 12 months, although longevity varies depending on the treatment area and individual metabolism.
Will my results look natural?
Yes. Restylane Refyne is specifically designed to preserve natural facial movement while softening facial lines, helping you look refreshed without appearing stiff or overfilled.
Does Restylane Refyne hurt?
Restylane Refyne contains lidocaine to improve comfort during treatment. Most patients describe the injections as causing only mild discomfort.
Is there any downtime?
Most patients return to normal daily activities immediately after treatment. Mild swelling, bruising, tenderness, or redness may occur and generally improves within several days.

